abstract：BACKGROUND:Mesalazine preparations are widely used to treat mild to moderately severe ulcerative colitis (UC). We compared once-daily administration of oral mesalazine in patients with quiescent UC with the established 3-times-daily prescription, assessing the efficacy and safety of each method in maintaining remission...

journal_title：Inflammatory bowel diseases

authors： Watanabe M,Hanai H,Nishino H,Yokoyama T,Terada T,Suzuki Y

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The incidence of inflammatory bowel disease (IBD) has increased over the past several decades with a corresponding increase in the number of patients on combination immunosuppressive therapy including corticosteroids, anti-metabolites and biologic agents. The exact incidence of pneumocystis jiroveci pneumoni...

journal_title：Inflammatory bowel diseases

authors： Okafor PN,Nunes DP,Farraye FA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract that significantly impacts the health-related quality of life (HR-QOL). A decreased HR-QOL has been demonstrated in patients with active disease compared with patients in remission. In this cross-sectional study, we e...

journal_title：Inflammatory bowel diseases

authors： Zhang CK,Hewett J,Hemming J,Grant T,Zhao H,Abraham C,Oikonomou I,Kanakia M,Cho JH,Proctor DD

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Female patients receiving immunosuppressive therapy may be at increased risk for human papillomavirus (HPV) infection and cervical neoplasia. METHODS:We administered the 3-dose HPV vaccine Gardasil to 37 females aged 9 to 26 years with inflammatory bowel disease (IBD) prescribed immunosuppressive therapy (p...

journal_title：Inflammatory bowel diseases

authors： Jacobson DL,Bousvaros A,Ashworth L,Carey R,Shrier LA,Burchett SK,Renna H,Lu Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Nonadherence to medications may affect disease outcomes. The aim of this article was to review methods of assessment, prevalence, and predictors of nonadherence to anti-tumor necrosis factor therapy in inflammatory bowel diseases (IBD). METHODS:Studies were identified through the electronic database of MEDL...

journal_title：Inflammatory bowel diseases

authors： Lopez A,Billioud V,Peyrin-Biroulet C,Peyrin-Biroulet L

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that the downregulation of pregnane X receptor (PXR) may contribute to the susceptibility and exacerbation of Crohn's disease (CD). Because bile acid malabsorption is one of the features of CD and bile acids are potential activators of PXR, we explored the relationship between b...

journal_title：Inflammatory bowel diseases

authors： Iwamoto J,Saito Y,Honda A,Miyazaki T,Ikegami T,Matsuzaki Y

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

journal_title：Inflammatory bowel diseases

authors： Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Up to 20% of patients with ulcerative colitis (UC) become steroid-dependent during their course. Thiopurines are recommended in steroid-dependent UC, but their efficacy is debated. Data exploring the use of infliximab in these patients are scarce. Aims of this study were to evaluate the effectiveness of infl...

journal_title：Inflammatory bowel diseases

authors： Armuzzi A,Pugliese D,Danese S,Rizzo G,Felice C,Marzo M,Andrisani G,Fiorino G,Sociale O,Papa A,De Vitis I,Rapaccini GL,Guidi L

更新日期：2013-04-01 00:00:00

abstract：:Skin manifestations are common in patients suffering from inflammatory bowel disease (IBD) and can be associated with the disease itself, with nutritional deficiencies, or with therapy. All drugs currently used for treating IBD have the potential to cause dermatologic manifestations that can have a wide range of clini...

journal_title：Inflammatory bowel diseases

authors： Torres J,Buche S,Delaporte E,Colombel JF

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Antimicrobial peptides (AMPs) maintain a sterile environment in intestinal crypts, limiting microbial colonization and invasion. Decreased AMP expression is proposed to increase the risk for inflammatory bowel disease. Expression and function of inducible AMPs, human β-defensin 2 and 3 (hBD-2 and hBD-3), rem...

journal_title：Inflammatory bowel diseases

authors： Meisch JP,Nishimura M,Vogel RM,Sung HC,Bednarchik BA,Ghosh SK,Fu P,McCormick T,Weinberg A,Levine AD

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is associated with a high risk of deep venous thromboembolism. However, few data are available so far on portomesenteric vein thrombosis (PMVT). The aim of this study was to describe the characteristics of PMVT in patients with IBD. METHODS:A retrospective study was conducte...

journal_title：Inflammatory bowel diseases

authors： Landman C,Nahon S,Cosnes J,Bouhnik Y,Brixi-Benmansour H,Bouguen G,Colombel JF,Savoye G,Coffin B,Abitbol V,Filippi J,Laharie D,Moreau J,Veyrac M,Allez M,Marteau P,Groupe d'Etude Thérapeutique des Affections Inflammatoires

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis in UC for more than a decade, little is known of its cellular consequences. METHODS:Whole-genome gene expression analys...

journal_title：Inflammatory bowel diseases

authors： Gerling M,Nousiainen K,Hautaniemi S,Krüger S,Fritzsche B,Homann N,Bruch HP,Auer G,Roblick UJ,Ried T,Habermann JK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Pharmacologic inhibition or genetic ablation of phosphoinositide 3-kinase gamma (PI3Kγ) has been shown to be protective against experimental colitis. However, the role of PI3Kγ in the resolution phase of colitis remains unexplored. In this study, we assess the effects of genetic knockout of PI3Kγ on the indu...

journal_title：Inflammatory bowel diseases

authors： Prescott D,Atkinson B,Döring A,Brown S,Petri B,McKay DM,Waterhouse CC

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The clinical course of ulcerative colitis (UC) is unpredictable. During recent years, the ability of fecal biomarkers to predict relapse in inflammatory bowel disease has been evaluated. The objective of this study was to assess fecal calprotectin (FC) as a predictor of disease recurrence in patients with ne...

journal_title：Inflammatory bowel diseases

authors： Lasson A,Simrén M,Stotzer PO,Isaksson S,Ohman L,Strid H

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The clinical utility of cellular therapies is being investigated in a broad range of therapeutic areas. This phase 1 study represents the first exploration of PDA001, a preparation of cells cultured from human placental tissue, in subjects with Crohn's disease. METHODS:Twelve subjects with active, moderate-...

journal_title：Inflammatory bowel diseases

authors： Mayer L,Pandak WM,Melmed GY,Hanauer SB,Johnson K,Payne D,Faleck H,Hariri RJ,Fischkoff SA

更新日期：2013-03-01 00:00:00

abstract：:The risk of colorectal cancer in patients with long-standing ulcerative colitis or colonic Crohn's disease is increased. Patients with long-standing ulcerative colitis are offered enrollment into programs of endoscopic surveillance. Although direct evidence for a protective effect of surveillance against death from co...

journal_title：Inflammatory bowel diseases

authors： Collins PD

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The etiology of ulcerative colitis (UC) and Crohn's disease (CD) involves both genetic and environmental components. Multiple UC and CD susceptibility genes have been identified through genome-wide association studies and subsequent meta-analyses. These studies have also highlighted the presence of genes com...

journal_title：Inflammatory bowel diseases

authors： Doecke JD,Simms LA,Zhao ZZ,Huang N,Hanigan K,Krishnaprasad K,Roberts RL,Andrews JM,Mahy G,Bampton P,Lewindon P,Florin T,Lawrance IC,Gearry RB,Montgomery GW,Radford-Smith GL

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Extracorporeal photopheresis (ECP) involves ex vivo leukocyte treatment with methoxsalen and UVA light to generate a tolerogenic response. A previous trial demonstrated that ECP permits corticosteroid withdrawal in steroid-dependent Crohn's disease (CD) patients who were in clinical remission. We studied the...

journal_title：Inflammatory bowel diseases

authors： Reinisch W,Knobler R,Rutgeerts PJ,Ochsenkühn T,Anderson F,von Tirpitz C,Kaatz M,Janneke van der Woude C,Parenti D,Mannon PJ

更新日期：2013-02-01 00:00:00

abstract：:The traditional goals of Crohn's disease therapy, to induce and maintain clinical remission, have not clearly changed its natural history. In contrast, emerging evidence suggests that achieving and maintaining mucosal healing may alter the natural history of Crohn's disease, as it has been associated with more sustain...

journal_title：Inflammatory bowel diseases

authors： De Cruz P,Kamm MA,Prideaux L,Allen PB,Moore G

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The purpose was to estimate the incidence and characteristics of childhood inflammatory bowel disease (IBD) during 2000-2010 in Shanghai, China. METHODS:IBD patients between the ages of 0 and 18 years old were identified by survey of computerized medical information. Relevant data were extracted from their ...

journal_title：Inflammatory bowel diseases

authors： Wang XQ,Zhang Y,Xu CD,Jiang LR,Huang Y,Du HM,Wang XJ

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The clinical implication of Clostridium difficile infection (CDI) in patients with ileal pouch-anal anastomosis (IPAA) for underlying inflammatory bowel disease (IBD) has not been well studied. This study was designed to investigate the cumulative incidence, risk factors, and outcome of CDI in patients with ...

journal_title：Inflammatory bowel diseases

authors： Li Y,Qian J,Queener E,Shen B

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Although magnetic resonance imaging (MRI) is an increasingly used diagnostic tool in the assessment of inflammatory bowel disease (IBD) in humans, diagnosis and quantitation of intestinal inflammation in animal models of IBD still depends on ex vivo techniques. The aim of this study was to evaluate whether h...

journal_title：Inflammatory bowel diseases

authors： Michael S,Keubler LM,Smoczek A,Meier M,Gunzer F,Pöhlmann C,Krause-Buchholz U,Hedrich HJ,Bleich A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) affects people during their prime reproductive years. The thiopurines (6-mercaptopurine and azathioprine), commonly used for induction and maintenance of remission, are U.S. Food and Drug Administration (FDA) pregnancy category D, raising concern for fetal risk. We performed ...

journal_title：Inflammatory bowel diseases

authors： Akbari M,Shah S,Velayos FS,Mahadevan U,Cheifetz AS

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) of the pouch can develop in patients with ileal pouch-anal anastomosis, resulting in significant morbidities, even pouch failure. The aim of this study was to evaluate short- and long-term outcome of adalimumab (ADA) in treating these patients. METHODS:A total of 48 patients who receive...

journal_title：Inflammatory bowel diseases

authors： Li Y,Lopez R,Queener E,Shen B

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The widespread use of the Internet allows for unique research opportunities. We aimed to develop and follow an Internet-based cohort (e-cohort) of patients with self-reported inflammatory bowel diseases (IBD) over time. METHODS:We established an e-cohort of adults with IBD (CCFA Partners) by recruiting thro...

journal_title：Inflammatory bowel diseases

authors： Long MD,Kappelman MD,Martin CF,Lewis JD,Mayer L,Kinneer PM,Sandler RS

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Assimilation of the preferred nutrient of enterocytes is mediated primarily by sodium (Na)-dependent cotransport (NGct) in the intestine. The predominant NGcT in villus cells, B0AT1, is inhibited secondary to a decrease in cotransporter numbers during chronic intestinal inflammation. In contrast, NGcT mediat...

journal_title：Inflammatory bowel diseases

authors： Arthur S,Saha P,Sundaram S,Kekuda R,Sundaram U

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Guidelines mandate screening for latent tuberculosis infection (LTBI) prior to anti-tumor necrosis factor (anti-TNF) therapy in patients with inflammatory bowel disease (IBD). However, many are already on immunosuppressive therapy (IST) that may affect the precision of the Tuberculin skin test (TST). Our aim...

journal_title：Inflammatory bowel diseases

authors： Shahidi N,Fu YT,Qian H,Bressler B

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Many treatment options exist for children with inflammatory bowel disease (IBD), yet the lack of clinical guidelines for management has lead to great variation in care. The purpose of this project was to evaluate current treatment modalities in children from the Northeast US who applied to the 2010 session o...

journal_title：Inflammatory bowel diseases

authors： Rosen D,Kathy-Hoffstadter-Thal,Bao R,Tomaino J,Ceballos C,Russell GJ,Benkov KJ

更新日期：2012-10-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has classically been associated with malnutrition and weight loss, although this has become less common with advances in treatment and greater proportions of patients attaining clinical remission. However, micronutrient deficiencies are still relatively common, particularly in CD patie...

journal_title：Inflammatory bowel diseases

authors： Hwang C,Ross V,Mahadevan U

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The cumulative incidence of colectomy and the impact of 5-aminosalicylates (5-ASA), azathioprine, and antitumor necrosis factor (TNF) treatment on the long-term need for surgery are unknown in ulcerative colitis (UC) in the era of biologics. METHODS:This was an observational study of a referral center cohor...

journal_title：Inflammatory bowel diseases

authors： Williet N,Pillot C,Oussalah A,Billioud V,Chevaux JB,Bresler L,Bigard MA,Gueant JL,Peyrin-Biroulet L

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:There has been a remarkable increase in the incidence of Crohn's disease (CD) among Arabs in recent years. We conducted this study to determine the clinical epidemiology of CD in Kuwait. METHODS:Sociodemographic and clinical information was collected for a continuous series of 206 Arab patients with CD and ...

journal_title：Inflammatory bowel diseases

authors： Siddique I,Alazmi W,Al-Ali J,Al-Fadli A,Alateeqi N,Memon A,Hasan F

更新日期：2012-09-01 00:00:00

abstract：:An interleukin (IL)-10 family cytokine, IL-22 is characterized by several unique biological properties, including 1) the target restricted to innate cells; 2) the distinct expression pattern between large and small intestines; 3) alteration of the cellular source depending on several factors; 4) the dual abilities to ...

journal_title：Inflammatory bowel diseases

authors： Mizoguchi A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The dsRNA-activated protein kinase (PKR) phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), a global regulator of protein synthesis in mammals. In addition, PKR activates several signal transduction pathways including STAT3 and AKT. PKR is activated by a number of inflammator...

journal_title：Inflammatory bowel diseases

authors： Cao SS,Song B,Kaufman RJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:We sought to investigate whether variants in genes involved in bacterial sensing and autophagy (NOD2, TLR5, IRGM, ATG16L1) and the interleukin-23 signaling pathway (IL12B, IL23R, STAT3) were associated with development of antimicrobial antibodies in patients with Crohn's disease (CD). METHODS:A cohort of 61...

journal_title：Inflammatory bowel diseases

authors： Murdoch TB,Xu W,Stempak JM,Landers C,Targan SR,Rotter JI,Silverberg MS

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Ideal biomarkers are required to be developed for the diagnosis and prediction of the treatment of inflammatory bowel disease (IBD). We have reported that alteration of N-linked oligosaccharides of immunoglobulin (Ig) G is a novel diagnostic marker of IBD. Oligosaccharide alterations of IgA, however, have no...

journal_title：Inflammatory bowel diseases

authors： Inoue T,Iijima H,Tajiri M,Shinzaki S,Shiraishi E,Hiyama S,Mukai A,Nakajima S,Iwatani H,Nishida T,Mizushima T,Yasui T,Isaka Y,Kanto T,Tsujii M,Miyoshi E,Wada Y,Takehara T

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) negatively affects health-related quality of life (HRQoL), but population-based and long-term data on this topic are scarce. Our aim was to determine the HRQoL in UC patients after a 10-year disease duration. METHODS:UC patients from a population-based inception cohort met at a presc...

journal_title：Inflammatory bowel diseases

authors： Hoivik ML,Moum B,Solberg IC,Cvancarova M,Hoie O,Vatn MH,Bernklev T,IBSEN Study Group.

更新日期：2012-08-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) may directly result in morbidity and rarely mortality from complications such as colorectal cancer or sepsis. Mortality rates compared with the matched general population, measured by standardized mortality ratio, may therefore be increased. This review examines the evi...

journal_title：Inflammatory bowel diseases

authors： Selinger CP,Leong RW

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective biologic that has shown efficacy in ulcerative colitis (UC) and Crohn's disease (CD). We studied the pharmacokinetics, pharmacodynamics, safety, tolerability, and efficacy of a new formulation of vedolizumab produced by an improved manufacturing process. METHODS:UC patients we...

journal_title：Inflammatory bowel diseases

authors： Parikh A,Leach T,Wyant T,Scholz C,Sankoh S,Mould DR,Ponich T,Fox I,Feagan BG

更新日期：2012-08-01 00:00:00

abstract：:The diagnosis of inflammatory bowel disease (IBD) is traditionally based on a combination of clinical, endoscopic, histological, and radiological criteria. However, further testing is needed in cases of diagnostic uncertainty and in predicting disease course. This systematic review focuses on the potential for 10 sero...

journal_title：Inflammatory bowel diseases

authors： Prideaux L,De Cruz P,Ng SC,Kamm MA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) presumably caused by dysregulated immune responses to the gut microbiota. Genetic association studies have implicated dozens of chromosomal regions or loci in IBD susceptibility. The next challenge is to explain the indiv...

journal_title：Inflammatory bowel diseases

authors： Labbé C,Boucher G,Foisy S,Alikashani A,Nkwimi H,David G,Beaudoin M,Goyette P,Charron G,Xavier RJ,Rioux JD

更新日期：2012-06-01 00:00:00